关键词: 棉鼠, 感染性呼吸道疾病, 动物模型

Abstract: Sigmodon hispidus, belonging to the order Rodentia, family Hamsters, and genus Sigmodon, has a total of 8 species and genera. Among them, the hairy sigmodon and the yellow-bellied sigmodon are commonly used experimental animals, and the hairy sigmodon is more widely applied. Cotton mice are susceptible to a variety of human pathogens. The pathological features of pneumonia caused by their infection are highly similar to those of humans. Therefore, they have become important animal models for tuberculosis and viral respiratory diseases, especially in the study of paramyxoviridae viral infections, where they have significant advantages. This article systematically reviews the application and characteristics of cotton mice in the research of infectious respiratory diseases, with a focus on analyzing their applicability in bacterial (such as Mycobacterium tuberculosis) and viral (such as influenza virus, avian influenza virus, etc.) respiratory infection models, with the aim of providing scientific and technological workers with a more comprehensive basis for selecting animal models and promoting the development and application of cotton mice as a new type of experimental resource.

Key words: cotton rat, infectious respiratory disease, animal model